Cell Biologists Identify New Tumor Suppressor For Lung Cancer

Cancer and cell biology experts at the University of Cincinnati (UC) have identified a new tumor suppressor that may help scientists develop more targeted drug therapies to combat lung cancer. The study, led by Jorge Moscat, PhD, appears in the January 2009 issue of Molecular and Cellular Biology. Proto-oncogenes are genes that play a role in normal cell growth (turnover of cells and tissue) but, when genetically modified, can cause the out-of-control cell division that leads to cancer. Previous research had established that Ras, a proto-oncogene, is abnormally expressed in up to 25 percent of human lung cancers; however, researchers did not understand the specific cellular events by which abnormal Ras expression leads to transformati…

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Lung Cancer | admin July 22, 2010